• USA Home
  • 233630 - Cryptotanshinone - CAS 35825-57-1 - Calbiochem

EMAIL THIS PAGE TO A FRIEND
233630 Sigma-Aldrich

Cryptotanshinone - CAS 35825-57-1 - Calbiochem

Cryptotanshinone is shown to inhibit the constitutive STAT3 Tyr⁷⁰⁵ phosphorylation in DU145 prostate cancer cells independent of the IL-6/JAK/STAT3 signaling pathway.

Synonym: AMPK Signaling Activator VIII, Cryptotanshinone - CAS 35825-57-1 - Calbiochem

  • CAS Number 35825-57-1

  • Empirical Formula (Hill Notation) C19H20O3

  • Molecular Weight 296.36

  •  MDL number MFCD07636810

Purchase

Properties

Quality Level   100
assay   ≥95% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   orange
solubility   ethanol: 1 mg/mL
  DMSO: 5 mg/mL
shipped in   ambient
InChI   1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1
InChI key   GVKKJJOMQCNPGB-JTQLQIEISA-N

Description

General description

Cryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 µM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 µM). Cryptotanshinone is also reported to deplete cellular ATP level (by 75% in 12 h at 20 µM in C2C12 myotubes), resulting in an indirect activation of cellular AMPK pathways and an enhancement of insulin-stimulated cellular glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes (by ~1.3- and 1.9-fold, respectively). Cryptotanshinone is demonstrated to be an orally active hypoglycemic agent in ob/ob mice, db/db mice, and ZDF rats in vivo (600 mg/kg/day).

Packaging

10 mg in Plastic ampoule

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Shin, D.S., et al. 2009. Cancer Res.69, 193.
Kim, E.J., et al. 2007. Mol. Pharmacol.72, 62.

Safety & Documentation

Safety Information

Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?