• USA Home
  • 234491 - InSolution PD 153035 - Calbiochem

EMAIL THIS PAGE TO A FRIEND
234491 Sigma-Aldrich

InSolution PD 153035 - Calbiochem

Synonym: InSolution PD 153035 - Calbiochem

  • Empirical Formula (Hill Notation) C16H14BrN3O2

  • Molecular Weight 360.21

Purchase

Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, P to Q,
Quality Level   100
assay   ≥97% (HPLC)
form   liquid
potency   25 pM IC50
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   +2C to +8C
shipped in   wet ice

Description

General description

An extremely potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.

Packaging

500 μg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Target Ki: 6 pM against the tyrosine kinase activity of the epidermal growth factor receptor (EGFR)

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Physical form

A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234490) in DMSO.

Safety & Documentation

Safety Information

Flash Point(F) 
188.6 °F - (Dimethylsulfoxide)
Flash Point(C) 
87 °C - (Dimethylsulfoxide)
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?