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234505 Sigma-Aldrich

Compound 56 - CAS 171745-13-4 - Calbiochem

A cell-permeable, reversible, ATP-competitive, highly potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (IC₅₀ = 6 pM).

Synonym: 4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline, Compound 56 - CAS 171745-13-4 - Calbiochem

  • CAS Number 171745-13-4

  • Empirical Formula (Hill Notation) C18H18BrN3O2

  • Molecular Weight 388.26

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, P to Q,
assay   ≥97% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   -20C
color   white
solubility   DMSO: 200 mg/mL
shipped in   ambient

Description

General description

A cell-permeable, reversible, ATP-competitive, highly potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 6 pM).

A cell-permeable, reversible, ATP-competitive, highly potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (IC50 = 6 pM).

Packaging

500 μg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
EGFR

Product competes with ATP.

Reversible: yes

Target IC50: 6 pM against EGFR

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267.

Legal Information

Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.

Safety & Documentation

Safety Information

Documents

Certificate of Analysis (COA)

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