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235135 Sigma-Aldrich

Corticosterone - CAS 50-22-6 - Calbiochem

Corticosteroid hormone synthesized in response to stress.

Synonym: (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione, Reichstein’s substance H, Corticosterone - CAS 50-22-6 - Calbiochem

  • CAS Number 50-22-6

  • Empirical Formula (Hill Notation) C21H30O4

  • Molecular Weight 346.46

  •  MDL number MFCD00037715

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Properties

Quality Level   100
assay   ≥95% (HPLC)
form   crystalline powder
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   +15C to +30C
color   off-white
  white to tan
solubility   ethanol: 50 mg/mL
shipped in   ambient
InChI   1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChI key   OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Description

General description

Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered expression which eventually affects ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.

Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered genomic expression. Steroid-induced changes in protein synthesis eventually affect ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.

Packaging

1 g in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
Mineralocorticoid and glucocorticoid receptors

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Garvy, B.A., et al. 1993. Immunology80, 587.
DeKloet, E.R. 1992. Ann. N.Y. Acad. Sci.663, 357.
Joels, M., and deKloet, E.R. 1992. Trends Neurosci.15, 25.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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