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253300 Sigma-Aldrich

Deltamethrin - CAS 52918-63-5 - Calbiochem

Deltamethrin, CAS 52918-63-5, is a synthetic type II pyrethroid that acts as a potent inhibitor of calcineurin (protein phosphatase 2B; IC50 = 100 pM).

Synonym: (S)-α-Cyano-3-phenoxybenzyl(1R)- cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate, (S)-α-Cyano-3-phenoxybenzyl(1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate

  • CAS Number 52918-63-5

  • Empirical Formula (Hill Notation) C22H19Br2NO3

  • Molecular Weight 505.20

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology,
packaging   10 mg in Glass bottle (253300-10MG)
color   white
form   solid
shipped in   ambient
solubility   DMSO: 15 mg/mL
  ethanol: 1 mg/mL
storage condition   OK to freeze
brand family   Calbiochem
primary target IC50   100 pM against calcineurin (protein phosphatase 2B)
purity   ≥98% by TLC
storage conditions   +2C to +8C

Description

Biochem/physiol Actions

Cell permeable: no

Primary Target
protein phosphatase 2B

Product does not compete with ATP.

Reversible: no

Target IC50: 100 pM against calcineurin (protein phosphatase 2B)

General description

Synthetic type II pyrethroid insecticide. Potent inhibitor of calcineurin (protein phosphatase 2B, IC50 = 100 pM). May also have varied effects on ion channels. Causes an increase in neurotransmitter release at synapses and also increases intrasynaptosomal Ca2+ levels.

Synthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B; IC50 = 100 pM). May also have varied effects on ion channels. Causes an increase in neurotransmitter release at synapses, and increases intrasynaptosomal Ca2+ levels.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Richter, A., et al. 1995. Biochem. Pharmacol.49, 367.
Enan, E., and Matsumura, F. 1993. Biochem. Pharmacol. 45, 703.
Enan, E., and Matsumura, F. 1992. Biochem. Pharmacol.43, 1777.
Narahasi, T. 1992. Trends Pharmacol. Sci.13, 236.

Packaging

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid acid or alkali conditions.

Warning

H

Safety & Documentation

Safety Information

RTECS 
GZ1233000

Documents

Certificate of Analysis

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Protocols & Articles
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