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263275 Millipore

Desmosine

A novel quaternary pyridinium poly-amino acid present in elastin.

Synonym: Desmosine

  • Empirical Formula (Hill Notation) C24H39N5O8

  • Molecular Weight 525.60

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Properties

Related Categories Auxiliary Proteins, Biochemicals and Reagents, Other, Proteins and Derivatives
Quality Level   100
assay   ≥99% (TLC)
form   lyophilized
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   -20C
solubility   water: 10 mg/mL
shipped in   ambient

Description

General description

A novel quaternary pyridinium poly-amino acid present in elastin. Suggested to be responsible for the cross-linking of elastin leading to the formation of insoluble fibers. Urinary excretion of desmosine is a useful indicator of elastin breakdown resulting from increased elastase activity. Absorption max: 268 nm.

A novel quaternary pyridinium poly-amino acid present in elastin. Suggested to be responsible for the cross-linking of elastin leading to the formation of insoluble fibers. Urinary excretion of desmosine is a useful indicator of elastin breakdown resulting from increased elastase activity.

Packaging

5 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
Cross-linking of elastin

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Akagawa, M., and Suyama, K. 2000. Connect. Tissue Res.41, 131.
Bode, D.C., et al. 2000. Pulm. Pharmacol. Therap.13, 175.
Viglio, S., et al. 2000. Eur. Respir. J.15, 1039.
Davis, N.R., and Anwar, R.A. 1970. J. Am. Chem. Soc.92, 3778.
Thomas, J., et al. 1963. Nature200, 651.

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