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  • 264155 - Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem

264155 Sigma-Aldrich

Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem

The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym: Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem, Z-D(OMe)E(Ome)VD(OMe)-FMK

  • CAS Number 210344-95-9

  • Empirical Formula (Hill Notation) C30H41FN4O12

  • Molecular Weight 668.66



Related Categories A to C, Biochemicals and Reagents, Caspase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   200
assay   ≥90% (TLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   -20C
color   white to slightly brown
solubility   DMSO: 5 mg/mL
shipped in   ambient


General description

A potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.

A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/75 µl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.


1 mg in Plastic ampoule

250 μg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10

Product does not compete with ATP.

Reversible: no


Toxicity: Standard Handling (A)




Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature 376, 37.

Safety & Documentation

Safety Information

Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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