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287840 Sigma-Aldrich

Diclofenac Sodium - CAS 15307-79-6 - Calbiochem

A cell-permeable, non-selective cyclooxygenase inhibitor (IC₅₀ = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity.

Synonym: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na, Diclofenac Sodium - CAS 15307-79-6 - Calbiochem

  • CAS Number 15307-79-6

  • Empirical Formula (Hill Notation) C14H10Cl2NO2 · Na

  • Molecular Weight 318.13

  •  MDL number MFCD00082251

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Properties

Related Categories A to C, Biochemicals and Reagents, Cyclooxygenase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
assay   ≥98% (TLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   +15C to +30C
color   white
solubility   water: 25 mg/mL
shipped in   ambient
InChI   1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
InChI key   KPHWPUGNDIVLNH-UHFFFAOYSA-M

Description

General description

A cell-permeable, non-selective cyclooxygenase inhibitor (IC50 = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity. Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Also inhibits liver phenol sulfotransferase activity (IC50 = 9.5 µM).

A potent non-steroidal anti-inflammatory drug that inhibits both COX-1 (IC50 = 76 nM) and COX-2 (IC50 = 26 nM) activities. Also inhibits liver phenol sulfotransferase activity (IC50 ~9.5 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
COX-1

Product does not compete with ATP.

Reversible: no

Target IC50: 60 nM and 200 nM for ovine COX-1 and COX-2 respectively; 9.5 µM against liver phenol sulfotransferase activity

Warning

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Reconstitution

Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kato, M., et al. 2001. J. Pharm. Pharmacol.53, 1679.
Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.
Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81.
Merlos, M., et al. 1996. Inflamm. Res.45, 20.
Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473.
Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Protocols & Articles
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