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309866 Millipore

Diltiazem, Hydrochloride - CAS 33286-22-5 - Calbiochem

Synthetic benzothiazepine that acts as an L-type Ca2+ channel antagonist.

Synonym: L-Type Calcium Channel Blocker II

  • CAS Number 33286-22-5

  • Empirical Formula (Hill Notation) C22H26N2O4S · xHCl

  • Molecular Weight 414.52 (free base basis)

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Properties

Related Categories Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Ion Channels,
packaging   100 mg in Plastic ampoule (309866-100MG)
feature productdata solubility   H₂O (50 mg/ml), Methanol, or chloroform
brand family   Calbiochem
form   White solid
purity   ≥98% by HPLC
storage conditions   Hygroscopic
  Ok to freeze
shipped in   ambient
storage conditions   +15C to +30C

Description

Biochem/physiol Actions

Cell permeable: no

Primary Target
L-type Ca2+ channel

Product does not compete with ATP.

Reversible: no

General description

Synthetic (+)-cis isomer that acts as an L-type Ca2+ channel antagonist. Similar in function to nifedipine and verapamil. Has a negative inotropic effect on the heart. Strongly suppresses conductance at the A-V node and automatically at the S-A node. Has also been shown to regulate Ca2+ release from intracellular stores in neutrophils.

Synthetic benzothiazepine that acts as an L-type Ca2+ channel antagonist. Similar in function to Nifedipine (Cat. No. 481981) and Verapamil (Cat. No. 676777). Has negative inotropic effects on the heart. Strongly suppresses conductance at the A-V node and automaticity at the S-A node. Has also been shown to regulate Ca2+ release from intracellular stores in neutrophils.

Other Notes

van Zwieten, P.A., and Pfaffendorf, M. 1993. J. Hypertens. Suppl. 11, S3.
Rosales, C., and Brown, E.J. 1992. J. Biol. Chem. 267, 1443.
Julian, D.G. 1987. Am. J. Cardiol. 59, 37J.
Campbell, K.P., et al. 1986. Proc. Natl. Acad. Sci. USA83, 2792.
Gallizzi, J.P., et al. 1986. J. Biol. Chem.261, 1393.
Garcia, M.L., et al. 1986. J. Biol. Chem.261, 8146.

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.

Warning

E

Safety & Documentation

Safety Information

RTECS 
DL0310000

Documents

Certificate of Analysis

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Protocols & Articles
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