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317505 Sigma-Aldrich

1,2-Dioctanoyl-sn-glycerol - CAS 60514-48-9 - Calbiochem

Cell-permeable activator of protein kinase C (PKC).

Synonym: 1,2-Dioctanoyl-sn-glycerol - CAS 60514-48-9 - Calbiochem, DOG, PKC Activator IV

  • CAS Number 60514-48-9

  • Empirical Formula (Hill Notation) C19H36O5

  • Molecular Weight 344.49

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Protein Kinase C (PKC), Serine/Threonine Kinase Activators,
Quality Level   100
form   oil
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   = -70C
color   clear colorless
solubility   chloroform: soluble
  ethyl acetate: soluble
shipped in   wet ice
InChI   1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3/t17-/m0/s1
InChI key   ZQBULZYTDGUSSK-KRWDZBQOSA-N

Description

General description

Cell-permeable activator of protein kinase C (PKC). Exhibits lower affinity for PKCα than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells.

Cell-permeable activator of protein kinase C; however, it has lower affinity for PKCa than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells.

Packaging

10 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Protein kinase C

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Analysis Note

Single spot by TLC

Other Notes

Ferro, T.J., et al. 1993. Am. J. Physiol. 264, L7.
MacEwan, D.J., et al. 1993. Eur. J. Pharmacol. 246, 9.
Davis, R.J. 1985. J. Biol. Chem.260, 1562.

Safety & Documentation

Safety Information

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