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317641 Sigma-Aldrich

Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem

The Dipeptidylpeptidase IV Inhibitor III, also referenced under CAS 866396-34-1, controls the biological activity of Dipeptidylpeptidase IV. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym: 1-(((1-(Hydroxymethyl)cyclopentyl)amino)acetyl)-2,5-cis-pyrrolidinedicarbonitrile, HCl, DPP IV Inhibitor III, Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem

  • CAS Number 866396-34-1

  • Empirical Formula (Hill Notation) C14H20N4O2 · xHCl

  • Molecular Weight 276.33 (free base basis)

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Properties

Quality Level   100
assay   ≥97% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   +2C to +8C
color   white
solubility   PBS: 20 mg/mL
  ethanol: 20 mg/mL
  water: 20 mg/mL
shipped in   ambient

Description

General description

An orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC50 = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 µM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Wright, S.W., et al. 2006. J. Med. Chem.49, 3068.

Safety & Documentation

Safety Information

Protocols & Articles
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