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324380 Millipore

Doxorubicin, Hydrochloride - CAS 25316-40-9 - Calbiochem

Doxorubicin HCl, CAS 25316-40-9, is an antitumor antibiotic that inhibits topoisomerase II (IC₅₀ = 100 nM).

Synonym: Doxorubicin, Hydrochloride - CAS 25316-40-9 - Calbiochem

  • CAS Number 25316-40-9

  • Empirical Formula (Hill Notation) C27H29NO11 · xHCl

  • Molecular Weight 543.52 (free base basis)

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, R to Z,
assay   ≥98% (HPLC)
form   powder
potency   100 nM IC50
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
color   orange to red
solubility   water: 10 mg/mL
shipped in   ambient
storage conditions   +15C to +30C

Description

General description

An anti-tumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC50 = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, inhibiting nucleic acid synthesis. Cytotoxicity seems to be due to its ability to intercalate with DNA, interact with plasma membranes, and take part in oxidation-reduction reactions. Induces apoptosis in rhabdomyosarcoma cell lines.

Antitumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC50 = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, thereby inhibiting nucleic acid synthesis. Induces apoptosis in rhabdomyosarcoma cell lines. Also available as a 10 mM solution in H2O (Cat. No. 504042).

Doxorubicin HCl, CAS 25316-40-9, is an antitumor antibiotic that inhibits topoisomerase II (IC₅₀ = 100 nM).

Packaging

10 mg in Plastic ampoule

Biochem/physiol Actions

Primary Target
topoisomerase 2

Product does not compete with ATP.

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C. Under acidic conditions doxorubicin is converted to a water-insoluble adriamycinone and a water soluble reducing sugar, daunosamine.

Other Notes

A′Hern, R.P., and Gore, M.E. 1995. J. Clin. Oncol. 13, 726.
Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
Noviello, E., et al. 1994. Mutat. Res.311, 21.
Anderson, R.D., et al. 1993. Mutat. Res.294, 215.
Hershko, C., et al. 1993. J. Lab. Clin. Med.122, 245.
Jongmans, W., et al. 1993. Mutat. Res.294, 207.
O′Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc.270, 2089.
Theyer, G., et al. 1993. J. Urol.150, 1544.
Tritton, T.R., and Yee, G. 1982. Science217, 248.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis (COA)

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