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  • 324410 - Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem

324410 Sigma-Aldrich

Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem

Synonym: 3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin, Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem

  • CAS Number 304448-55-3

  • Empirical Formula (Hill Notation) C18H14N2O4

  • Molecular Weight 322.31

  •  NACRES NA.77



Quality Level   100
assay   ≥98% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
color   pale yellow
solubility   DMSO: 16 mg/mL
shipped in   ambient


General description

A cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.


10 mg in Plastic ampoule

Packaged under inert gas


Toxicity: Environmental Hazard (N)


Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Young, A., et al. 2009. Biochem. J., In press.
Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol.16, 607.
Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA103, 17955.
Macia. E., et al. 2006. Dev. Cell10, 839.

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