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324411 Sigma-Aldrich

Dynamin Inhibitor II, MiTMAB - CAS 1119-97-7 - Calbiochem

The Dynamin Inhibitor II, MiTMAB, also referenced under CAS 1119-97-7, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Synonym: Tetradecyl trimethyl ammonium Bromide, Myr istyl tri methyl ammonium Bromide, TTAB, Dynamin Inhibitor II, MiTMAB - CAS 1119-97-7 - Calbiochem

  • CAS Number 1119-97-7

  • Empirical Formula (Hill Notation) C17H38BrN

  • Molecular Weight 336.39

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Properties

Quality Level   100
assay   ≥99% (titration)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   +2C to +8C
color   white
solubility   DMSO: 10 mg/mL
  water: 100 mg/mL
shipped in   ambient

Description

General description

A cell-permeable cationic surfactant that reversibly inhibits dynamin GTPase activity (IC50 = 3.15 µM) by targeting the PH domain and interfering with phospholipid binding. Shown to block dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP.

Packaging

500 mg in Glass bottle

Packaged under inert gas

Warning

Toxicity: Corrosive (L)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Quan, A., et al. 2007. Mol. Pharmacol.72, 1425.
Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett.14, 3275.

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