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  • 324412 - Dynamin Inhibitor III, Phthaladyn-23 - Calbiochem

324412 Sigma-Aldrich

Dynamin Inhibitor III, Phthaladyn-23 - Calbiochem

Synonym: 4-Chloro-2-((2-(3-nitrophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl)-amino)-benzoic acid, Dynamin Inhibitor III, Phthaladyn-23 - Calbiochem

  • Empirical Formula (Hill Notation) C22H12ClN3O7

  • Molecular Weight 465.80



Quality Level   100
assay   ≥98% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   light yellow to beige
solubility   DMSO: 7 mg/mL
shipped in   ambient


General description

A cell-permeable phthalimide compound that is reported to inhibit dynamin GTPase activity (IC50 = 17.4 and 63 µM using purified sheep brain dynamin I and recombinant dynamin II, respectively) in a GTP-competitive manner. Shown to block K+-induced SVE (synaptic vesicle endocytosis) of FM4-64 dye into rat brain synaptosomes (IC50 = 12.9 µM), while being ineffective at 30 µM against RME (receptor-mediated endocytosis) of transferrin into human osteosarcoma epithelial U2OS cells, presumably due to poor dynamin II inhibitory potency and/or rapid efflux and/or limited permeability in this cell line.


10 mg in Glass bottle

Packaged under inert gas


Toxicity: Standard Handling (A)


Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Odell, L.R., et al. 2010. J. Med. Chem.53, 5267.

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