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  • 324519 - InSolution eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem

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324519 Sigma-Aldrich

InSolution eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem

Synonym: 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I, eIF4F Inhibitor I, 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid

  • CAS Number 315706-13-9

  • Empirical Formula (Hill Notation) C18H12Cl2N4O4S

  • Molecular Weight 451.28

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Properties

Related Categories Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression,
mfr. no.   Calbiochem
potency   25 μM Ki
storage condition   OK to freeze
  avoid repeated freeze/thaw cycles
  desiccated
  protect from light
storage conditions   = -70C
form   liquid
assay   ≥95% (sum of two isomers, HPLC)
shipped in   dry ice

Description

Biochem/physiol Actions

Cell permeable: yes

Primary Target
eIF4E

Reversible: yes

General description

A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC50 ~25 µM). Shown to be brain permeant and reduce neuroligin protein levels, and restore L-LTP threshold and rescue autistic-like behaviours in Eif4ebp2 knockout mice.

Other Notes

Gkogkas, C.G., et al. 2012. Nature493, 371.
Moerke, N. J., et al. 2007. Cell128, 257.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Reconstitution

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Warning

Toxicity: Irritant (B)

Physical form

A 25 mM (5 mg/443 µL) solution of eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 (Cat. No. 324517)

Safety & Documentation

Safety Information

Documents

Certificate of Analysis

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