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324688 Sigma-Aldrich

Ellipticine - CAS 519-23-3 - Calbiochem

A cell-permeable antitumor alkaloid that acts as an inhibitor of topoisomerase II and acts as an intercalative agent that stimulates topoisomerase II-mediated DNA breakage.

Synonym: 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole, 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole

  • CAS Number 519-23-3

  • Empirical Formula (Hill Notation) C17H14N2

  • Molecular Weight 246.31

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, R to Z,
packaging   10 mg (324688-10MG)
feature productdata solubility   DMSO (5 mg/ml) or Ethanol (1 mg/ml)
brand family   CBC
form   Bright yellow solid
purity   ≥99% by HPLC
shipped in   3
storage conditions   15
  N

Description

Biochem/physiol Actions

Cell permeable: yes

Primary Target
topoisomerase 2

Product does not compete with ATP.

Reversible: no

General description

A cell-permeable antitumor alkaloid that acts as an inhibitor of topoisomerase II and acts as an intercalative agent that stimulates topoisomerase II-mediated DNA breakage. Is also capable of uncoupling mitochondrial oxidative phosphorylation.

A topoisomerase II inhibitor. Acts as an intercalative alkaloid that stimulates topoisomerase II-mediated DNA breakage. Is also capable of uncoupling mitochondrial oxidative phosphorylation.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Froelich-Ammon, S.J., et al. 1995. J. Biol. Chem. 270, 14998.
Schwaller, M.A., et al. 1995. J. Biol. Chem.270, 22709.
Pommier, Y., et al. 1985. Biochemistry24, 6406.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxic & Carcinogenic (G)

Safety & Documentation

Safety Information

RTECS 
UU8825000
Protocols & Articles
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