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324732 Sigma-Aldrich

ErbB2 Inhibitor II - CAS 928207-02-7 - Calbiochem

The ErbB2 Inhibitor II, also referenced under CAS 928207-02-7, controls the biological activity of ErbB2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: 4-(3-Phenoxyphenyl)-5-cyano-2H-1,2,3-triazole, 4-(3-Phenoxyphenyl)-5-cyano-2H-1,2,3-triazole

  • CAS Number 928207-02-7

  • Empirical Formula (Hill Notation) C15H10N4O

  • Molecular Weight 262.27

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, P to Q,
packaging   5 mg in Plastic ampoule (324732-5MG)
feature productdata solubility   DMSO (50 mg/ml)
brand family   CBC
form   Yellow solid
purity   ≥95% by HPLC
shipped in   3
storage conditions   15
  Y
  N

Description

General description

A cell-permeable triazole compound that targets the ATP-binding site of erbB2/HER2 and reduces the phosphorylation of erbB2 in MDA-MB-453 cells (IC50 = 6.6 µM), but not that of the overexpressed erbB1 in MDA-MB-468 cells even at concentrations as high as 100 µM. Shown to suppress MDA-MB-453 growth with an IC50 of 30.9 µM.

Other Notes

Cheng, Z. Y., et al. 2007. Bioorg. Med. Chem.15, 1533.

Packaging

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.

Warning

B

Safety & Documentation

Safety Information

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