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324896 Sigma-Aldrich

eIF-2α Inhibitor II, Sal003 - CAS 301359-91-1 - Calbiochem

The eIF-2α Inhibitor II, Sal003, also referenced under CAS 301359-91-1, controls the biological activity of eIF-2α. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: 3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide, Sal003, 3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide, Sal003

  • CAS Number 301359-91-1

  • Empirical Formula (Hill Notation) C18H15Cl4N3OS

  • Molecular Weight 463.21

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression, RNA-Protein Translation Inhibitors More...
packaging   5 mg in Plastic ampoule (324896-5MG)
color   off-white
mfr. no.   Calbiochem
storage condition   OK to freeze
  protect from light
storage conditions   -20C
form   solid
assay   ≥95% (HPLC)
solubility   DMSO: 10 mg/mL
shipped in   wet ice

Description

General description

A cell-permeable Salubrinal (Cat. No. 324895) analog that is reported to be more potent and soluble than Salubrinal. In addition to being a useful tool in studying elF2α-mediated cellular processes in cultures in vitro, enhanced elF2α phosphorylation by Sal003 treatment in the brain (40 pmol per animal) is shown to impair long-term memory in mice in vivo.

A cell-permeable Salubrinal (Cat. No. 324895) analog that is reported to be more potent and soluble than Salubrinal. In addition to being a useful tool in studying elF2α-mediated cellular processes in cultures in vitro, enhanced elF2α phosphorylation by Sal003 treatment in the brain (40 pmol per animal) is shown to impair long-term memory in mice in vivo.

Other Notes

Raven, J.F., et al. 2008. J. Biol. Chem.283, 3097.
Baltzis, D., et al. 2007. J. Biol. Chem.282, 31675.
Kazemi, S., et al. 2007. Mol. Biol. Cell18, 3635.
Costa-Mattioli, M., et al. 2007. Cell129, 195.
Robert, F., et al. 2006. Mol. Biol. Cell17, 4632.

Packaging

5 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Regulatory Review (Z)

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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