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341492 Sigma-Aldrich

FeTPPS - Calbiochem

A ferric porphyrin complex that catalytically isomerizes peroxynitrite to nitrate both in vivo and in vitro.

Synonym: 5,10,15,20-Tetrakis(4-sulfonatophenyl)porphyrinato Iron (III), Chloride, FeTPPS - Calbiochem

  • Empirical Formula (Hill Notation) C44H28ClFeN4O12S4

  • Molecular Weight 1024.27

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Properties

Related Categories Antioxidant and Free Radical Scavengers, Cancer Research, Cell Biology, Chemopreventive Agents
Quality Level   100
assay   ≥95% (TLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   +2C to +8C
color   dark brown
solubility   water: soluble
shipped in   ambient

Description

General description

A ferric porphyrin complex that catalytically isomerizes peroxynitrite to nitrate both in vivo and in vitro. Hence, serves as a selective peroxynitrite scavenger and decomposition catalyst. Provides cytoprotection against peroxynitrite (EC50 = 5 µM). Does not complex with nitric oxide and exhibits minimal SOD mimetic activity.

A ferric porphyrin complex that catalytically isomerizes peroxynitrite to nitrate both in vivo and in vitro. Provides cytoprotection against peroxynitrite (EC50 = 5 µM). Does not complex with nitric oxide and exhibits minimal SOD mimetic activity.

Packaging

25 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

EC50 = 5 µM for cytoprotection against peroxynitrite

Primary Target
Selective peroxynitrite scavenger

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.

Other Notes

Imam, S.Z., et al. 2000. Ann. N.Y. Acad. Sci.914, 157.
Misko, T.P., et al. 1998. J. Biol. Chem. 273, 15646.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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