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341598 Sigma-Aldrich

Fibroblast Growth Factor-2 Inhibitor, NSC37204 - Calbiochem

The Fibroblast Growth Factor-2 Inhibitor, NSC37204 controls the biological activity of Fibroblast Growth Factor-2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: Fibroblast Growth Factor-2 Inhibitor, NSC37204 - Calbiochem

  • Empirical Formula (Hill Notation) C21H14N2Na2O9S2

  • Molecular Weight 548.45

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Properties

Quality Level   100
assay   >95% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   -20C
color   brown
solubility   DMSO: 5 mg/mL
shipped in   wet ice

Description

General description

A small molecule, compound that is shown to compete with the binding domain of TSP-1 against angiogenic factor FGF-2 (IC50 = 1.3 µM) in a dose-dependent manner and prevents the binding of FGF-2 to HSPG on endothelial cells (IC50 = 24.0 ± 6.9 µM), in vitro. It also demonstrates anti-growth properties in FGF-2-induced, but not serum-induced, endothelial cells (IC50 = 20.3 µM ± 5.9 µM). In CAM assays in vivo, where angiogenesis is induced by FGF-2 embedded in gelatin sponges, the presence of the small molecule (0.5 µg) reduces the mean number of blood vessels entering the sponge from 26 ±4 (FGF-2 alone) to 10 ± 2 (FGF-2 + NSC37203).

A small molecule, compound that is shown to compete with the binding domain of TSP-1 against angiogenic factor FGF-2 (IC50 = 1.3 µM) in a dose-dependent manner and prevents the binding of FGF-2 to HSPG on endothelial cells (IC50 = 24.0 ±6.9 µM), in vitro. It also demonstrates anti-growth properties in FGF-2-induced, but not serum-induced, endothelial cells (IC50 = 20.3 µM ±5.9 µM). In CAM assays in vivo, where angiogenesis is induced by FGF-2 embedded in gelatin sponges, the presence of the small molecule (0.5 µg) reduces the mean number of blood vessels entering the sponge from 26 ±4 (FGF-2 alone) to 10 ±2 (FGF-2 + NSC37203).

Warning

Toxicity: Standard Handling (A)

Other Notes

Colombo, G., et al. 2010. J. Biol. Chem.285, 8733.

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