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  • 341610 - FGF/PDGF/VEGF RTK Inhibitor - CAS 144335-37-5 - Calbiochem

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341610 Sigma-Aldrich

FGF/PDGF/VEGF RTK Inhibitor - CAS 144335-37-5 - Calbiochem

The FGF/PDGF/VEGF RTK Inhibitor, also referenced under CAS 144335-37-5, controls the biological activity of FGF/PDGF/VEGF RTK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: 4-Hydroxy-3-benzimidazol-2-ylhydroquinolin-2-one, PDGFR Tyrosine Kinase Inhibitor XVII, VEGFR Tyrosine Kinase Inhibitor XXX, VEGFR2 Kinase Inhibitor XXVIII, FGF/PDGF/VEGF RTK Inhibitor - CAS 144335-37-5 - Calbiochem, PDGFR Tyrosine Kinase Inhibitor XVII, 4-Hydroxy-3-benzimidazol-2-ylhydroquinolin-2-one, VEGFR Tyrosine Kinase Inhibitor XXX, VEGFR2 Kinase Inhibitor XXVIII

  • CAS Number 144335-37-5

  • Empirical Formula (Hill Notation) C16H11N3O2

  • Molecular Weight 277.28

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, P to Q,
Quality Level   100
assay   ≥95% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   off-white
solubility   DMSO: 5 mg/mL
shipped in   ambient

Description

General description

A cell-permeable benzimidazolo-hydroquinolinone compound that acts as a potent, reversible, ATP-competitive inhibitor against PDGFRβ, FGFR-1, and VEGFR-2 (IC50 = 20, 90, and 240 nM, respectively) and effectively suppresses VEGF-stimulated proliferation of HMVECs (EC50 = 420 nM).

Packaging

5 mg in Plastic ampoule

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Renhowe, P.A., et al. 2009. J. Med. Chem.52, 278.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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