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344096 Millipore

InSolution Fluvastatin, Sodium Salt - CAS 93957-55-2 - Calbiochem

A synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent.

Synonym: (±)-(3Rʹ,5Sʹ,6E)-7-(3-(4-Fluorophenyl)-1-isopropylindol-2-yl)-3,5-dihydroxy-6-heptenoate, sodium, (±)-(3Rʹ,5Sʹ,6E)-7-(3-(4-Fluorophenyl)-1-isopropylindol-2-yl)-3,5-dihydroxy-6-heptenoate, sodium

  • CAS Number 93957-55-2

  • Empirical Formula (Hill Notation) C24H25FNNaO4

  • Molecular Weight 433.45

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Properties

Related Categories Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology More...
packaging   10 mg in Glass bottle (344096-10MG)
brand family   Calbiochem
form   Liquid
purity   ≥98% by HPLC
storage conditions   Avoid freeze/thaw
  Protect from light
  Ok to freeze
shipped in   dry ice
storage conditions   = -70C

Description

Biochem/physiol Actions

Reversible: yes

General description

A synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent. Unlike Lovastatin (Cat. No. >438185), Mevastatin (Cat. No. >474700), and Simvastatin (Cat. No. 567020), it does not require activation prior to use for in vitro studies. Reduces the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Fluvastatin is metabolized in the liver, primarily via hydroxylation of the indole ring at the 5- and 6-positions. N-Dealkylation and β-oxidation of the side-chain also occurs. The hydroxy metabolites are also reported to have some pharmacologic activity.

Other Notes

Yamamoto, A., et al. 2001. J. Pharm. Pharmacol.53, 227.
Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol.52, 145.
Ikeda, U., et al. 2000. Hypertension36, 325.
Levy, R.I., et al. 1993. Circulation87 (4 Suppl.), III45.
Tse, F.L.S. et al. 1992. J. Clin. Pharmacol.32, 630.
Yuan, J., et al. 1991. Atherosclerosis87, 147.

Packaging

Packaged under inert gas

Warning

Standard Handling (A)

Physical form

A 10 mM (10 mg/2.13 ml) solution of Fluvastatin, Sodium Salt (344095) in H₂O.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles
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