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  • 345752 - Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk

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345752 Sigma-Aldrich

Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk

Has been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma.

Synonym: Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk, Neu5Acα2,8Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, 2NH₄

  • Empirical Formula (Hill Notation) C70H123N3O30 · 2NH4

  • Molecular Weight 1522.80

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Properties

Related Categories Gangliosides, Glycan Component Classes, Glycobiology, Glycosphingolipids, Molecular Biology,
Quality Level   100
assay   ≥98% (TLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   -20C
color   white
solubility   water: 1 mg/mL
  chloroform/methanol (2:1): soluble
shipped in   ambient

Description

General description

Has been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma. Reported to disrupt mitochondrial transmembrane potential and induce apoptosis in tumor cells by a caspase-independent mechanism. Antibodies to GD3 can induce partial remission of tumor growth in animals and in humans via enhancement of cytotoxic and proliferative responses of lymphocytes. M.W. 1577.0 (based on tricosanoyl - 23:0).

Packaging

1 mg in Plastic ampoule

Warning

Toxicity: Irritant (B)

Other Notes

DeMaria, R., et al. 1997. Science 277, 1652.

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