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  • 345832 - Galectin-3C, Human, Recombinant, E. coli

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345832 Sigma-Aldrich

Galectin-3C, Human, Recombinant, E. coli

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Properties

Quality Level   100
assay   ≥95% (SDS-PAGE)
form   lyophilized
mfr. no.   Calbiochem®
storage condition   OK to freeze
  avoid repeated freeze/thaw cycles
storage conditions   -20C
impurities   ≤1 EU/μg protein Endotoxin
solubility   sterile PBS: 1 mg/mL
shipped in   wet ice

Description

General description

Recombinant, human galectin-3 expressed in E. coli and subsequently cleaved with Clostridium histiolyticum collagenase type VII to yield galectin-3C. The resulting galectin-3C is purified by affinity chromatography. Galectin-3C is a truncated form of galectin-3 that contains the carbohydrate binding domain but lacks the 107 amino acids at the N-terminus of galectin-3. It is suggested to play a key role in autoimmune diseases, allergic reactions, inflammation, tumor cell metastasis, atherosclerosis, and diabetes.

Recombinant, human galectin-3 expressed in E. coli and subsequently cleaved with Clostridium histolyticum collagenase type VII to yield galectin-3C. The resulting galectin-3C is purified by affinity chromatography. Galectin-3C is a truncated form of galectin-3 that contains the carbohydrate binding domain but lacks the 107 amino acids at the N-terminus of galectin-3. It is suggested to play a key role in autoimmune diseases, allergic reactions, inflammation, tumor cell metastasis, atherosclerosis, and diabetes.

Packaging

100 μg in Plastic ampoule

Warning

Toxicity: Standard Handling (A)

Physical form

Lyophilized from deionized water, 2µg lactose/µg lectin.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions (in the presence of a molar excess of lactose) are stable for up to 4 months at -20°C. For use in carbohydrate binding assays the solution should be dialyzed to remove the lactose stabilizer.

Other Notes

Hoyer K.K., et al. 2004. Am. J. Pathol.164, 893.
John C.M., et al. 2003. Clin. Cancer Res.9, 2374.
Iurisci, I., et al. 2000. Clin Cancer Res6, 1389.
Van Den Brule, F. A., et al. 2000. Int. J. Cancer89, 361.
Inohara, H. 1999. Cancer85, 2475.
Nakamura, M., et al. 1999. Int. J. Oncol.15, 143.
Idikio, H., et al. 1998. Int. J. Oncol.12, 1287.
Ochieng, J., et al. 1998. Biochim. Biophys. Acta.1379 97.
Castronovo, V., et al. 1996. J. Pathol.179, 43.
Liu, F.T., et al. 1996. Biochemistry35 6073.
Schoeppner, H. L., et al. 1995. Cancer75, 2818.
Massa, S.M., et al. 1993. Biochemistry32, 260.
Oda, Y., et al. 1991. Gene99, 279.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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