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361554 Sigma-Aldrich

GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem

The GSK-3β Inhibitor XII, TWS119, also referenced under CAS 601514-19-6, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem, Neurogenesis Inducer, TWS119

  • CAS Number 601514-19-6

  • Empirical Formula (Hill Notation) C18H14N4O2

  • Molecular Weight 318.33

  •  MDL number MFCD09037535

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Properties

Related Categories Biochemicals and Reagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates,
Quality Level   100
assay   ≥95% (HPLC)
form   solid
potency   30 nM IC50
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   beige
solubility   methanol: 2 mg/mL
  DMSO: 200 mg/mL
shipped in   ambient

Description

General description

A cell-permeable and potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).

A cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).

Packaging

1, 5 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Kd = 126 nM against GSK-3β

Primary Target
GSK-3β

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Ding, S., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7632.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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