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361568 Sigma-Aldrich

GSK-3β Inhibitor XXV - Calbiochem

The GSK-3β Inhibitor XXV controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: 5-(4-Nitrophenyl)-N-(3-chloro-4-methyl)phenyl-1,3,4-oxadiazol-2-amine, N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine, M SEW00923SC, GSK-3β Inhibitor XXV - Calbiochem

  • Empirical Formula (Hill Notation) C15H11ClN4O3

  • Molecular Weight 330.73

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Properties

Related Categories Biochemicals and Reagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates,
Quality Level   100
assay   ≥99% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   yellow
solubility   DMSO: 10 mg/mL
shipped in   ambient

Description

General description

A blood brain barrier permeable oxadiazole compound that acts as a potent, reversible and ATP-competitive inhibitor of GSK-3β activity (IC50 = 17.1 nM) with excellent selectivity over Cdk2 (22% inhibition at 10 µM). Shown to elevate liver glycogen levels by ~3.5- and ~4.3-fold in C57BL/6N mice when dosed at 5 and 15 mg/kg (i.p.) amounts.

Packaging

10 mg in Glass bottle

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Khanfar, M.A., et al. 2010. J. Med. Chem.53, 8534.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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