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365252 Sigma-Aldrich

Gö 7874, Hydrochloride - CAS 287935-76-6 - Calbiochem

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC₅₀ = 4 nM for rat brain PKC).

Synonym: Gö 7874, Hydrochloride - CAS 287935-76-6 - Calbiochem, MLCK Inhibitor III

  • CAS Number 287935-76-6

  • Empirical Formula (Hill Notation) C27H26N4O4 · xHCl

  • Molecular Weight 470.52 (free base basis)

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
assay   ≥97% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   amber
solubility   DMSO: 25 mg/mL
shipped in   ambient

Description

General description

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC50 = 4 nM for rat brain PKC). Inhibits protein kinase A (IC50 = 510 nM), protein kinase G (IC50 = 4.8 µM), and myosin light chain kinase (IC50 = 120 nM) at much higher concentrations.

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of rat brain protein kinase C (IC50 = 4 nM) versus myosin light chain kinase (IC50 = 0.12 µM), protein kinase A (IC50 = 510 nM), and protein kinase G (IC50 = 4.8 µM).

Packaging

500 μg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PKC

Product competes with ATP.

Reversible: yes

Target IC50: 4 nM against rat brain PKC

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Kleinschroth, J., et al. 1995. Bioorg. Med. Chem. Lett.5, 55.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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