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  • 370677 - Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt - Calbiochem

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370677 Sigma-Aldrich

Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt - Calbiochem

A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II.

Synonym: Rp-8- pCPT-cGMPS, TEA, PKG Inhibitor III, Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt - Calbiochem

  • Empirical Formula (Hill Notation) C16H15ClN5O6PS2 · xC6H15N

  • Molecular Weight 503.88 (free acid basis)

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, P to Q,
assay   ≥99% (HPLC)
form   lyophilized
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
solubility   water: 0.5 mg/mL
  DMSO: soluble
shipped in   ambient
storage conditions   -20C

Description

General description

A potent, cell-permeable inhibitor of protein kinase G Iα, Iβ, and type II. A combination of the protein kinase inhibitor Rp-cGMPS and the widely used cGMP analog, 8-pCPT-cGMP. Significantly more lipophilic and membrane-permeant than Rp-cGMPS and Rp-8-Br-cGMPS. Resistant to hydrolysis by mammalian cyclic nucleotide dependent phosphodiesterases. Note: 1 µmol = 0.61 mg.

A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II. Significantly more lipophilic and membrane-permeable than Rp-cGMPS or Rp-8-Br-cGMPS (Cat. No. 370674). Note: 1 µmol = 0.61 mg.

Packaging

1 umol in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PKG1α

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Abd Alla, S., et al. 1996. Eur. J. Biochem.241, 498.
Lee, S.J., et al. 1996. Dev. Biol.180, 324.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol.60, 94.
Willmott, N., et al. 1996. J. Biol. Chem.271, 3699.
Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.

Legal Information

Sold under license of U.S. Patent 5,625,056, Patents DE 3,802,865.4, and DE 4,217,679 issued to BIOLOG LSI.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis (COA)

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