• USA Home
  • 370679 - Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt - CAS 172806-20-1 - Calbiochem

EMAIL THIS PAGE TO A FRIEND
370679 Sigma-Aldrich

Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt - CAS 172806-20-1 - Calbiochem

A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM).

Synonym: Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt - CAS 172806-20-1 - Calbiochem, Rp-8-Br-PET-cGMPS, Na, PKG Inhibitor VI

  • CAS Number 172806-20-1

  • Empirical Formula (Hill Notation) C18H14BrN5O6PS · Na

  • Molecular Weight 562.27

Purchase

Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, P to Q,
Quality Level   100
assay   ≥98% (HPLC)
form   lyophilized
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   -20C
solubility   water: 5 mg/mL
shipped in   ambient

Description

General description

A metabolically-stable, competitive inhibitor of protein kinase G type Iα and Iβ (Ki = 30 nM) that also blocks cGMP-gated retinal type ion channels (IC50 = 25 µM). Also reported to block the activation of purified PKA type II (Ki = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 5 µmol = 2.81 mg.

A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM). Blocks cGMP-gated retinal type ion channels (IC50 = 25 µM) and the activation of purified PKA type II (Ki = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 1 µmol = 0.56 mg.

Packaging

1 μmol in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PKG1α & 1β

Product does not compete with ATP.

Reversible: no

Target Ki: 30 nM against PKG1α & 1β

Warning

Toxicity: Standard Handling (A)

Other Notes

Wei, J.Y., et al. 1996. Biochemistry35, 16815.
Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?