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  • 371758 - GPR81 Agonist, 3Cl-5OH-BA - CAS 53984-36-4 - Calbiochem

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371758 Sigma-Aldrich

GPR81 Agonist, 3Cl-5OH-BA - CAS 53984-36-4 - Calbiochem

Synonym: Hydroxycarboxylic Acid Receptor 1 Agonist, 3-Chloro-5-hydroxybenzoic acid

  • CAS Number 53984-36-4

  • Linear Formula C₇H₅ClO₃

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Properties

Related Categories Bioactive Small Molecules, Cell Biology More...
brand family   Calbiochem
packaging   100 mg in Glass bottle (371758-100MG)
form   Light beige solid
reversible   Y
primary target   GPR81
purity   ≥98% by HPLC
toxicity   Standard Handling
shipped in   ambient
storage temp.   +2C to +8C
storage conditions   Protect from light
  Ok to freeze

Description

Overview

A hydroxybenzoic acid compound that acts as a GPR81/HCA1-selective agonist (EC50 ~ 7, 16, 17, 22, and 67 µM toward rat, human, monkey, mouse, and dog species, respectively) with little activity towards the homologous GPR109A/HCA2/HM74A GPCR (EC50 >1 mM). Displays good pharmacokinetic characteristics in mice (Cmax/t1/2 = 67.2 µM/1.47 h and 341.9 µM/1.1 h, respectively, upon oral dosing at 30 mg/kg and 100 mg/kg) and exhibits NEFAc- (non-esterified free fatty acid cholesterol) lowering efficacy in overnight fasted C57B16/J mice (ED50 ~100 mg/kg, p.o.) in vivo.

A hydroxybenzoic acid compound that acts as a GPR81/HCA1-selective agonist (EC50 ~ 7, 16, 17, 22, and 67 µM toward rat, human, monkey, mouse, and dog species, respectively) with little activity towards the homologous GPR109A/HCA2/HM74A GPCR. Orally active in mice and exhibits NEFAc cholesterol-lowering efficacy in overnight fasted C57B16/J mice (ED50 ~100 mg/kg, p.o.) in vivo.

Packaging

Packaged under inert gas

Storage and Shipping Instructions

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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