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371780 Sigma-Aldrich

GP Antagonist-2A - Calbiochem

The GP Antagonist-2A controls the biological activity of GP. This small molecule/inhibitor is primarily used for Neuroscience applications.

Synonym: GP Antagonist-2A - Calbiochem, RPKPQQDWFDWDWM

  • Empirical Formula (Hill Notation) C79H105N21O13S

  • Molecular Weight 1588.88

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Properties

Related Categories Antagonists, Cell Biology, Cell Signaling and Neuroscience, Cholinergics, Endothelins,
Quality Level   100
assay   ≥95% (HPLC)
form   lyophilized solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   -20C
solubility   water: 25 mg/mL
shipped in   ambient

Description

General description

A peptide that selectively inhibits the activation of Gq by M1-muscarinic cholinergic receptors. Also inhibits activation by cholecystokinin receptor in pancreatic acini at 10 µM. Blocks angiotensin II-stimulated sis-inducing factor and STAT3 tyrosine phosphorylation.

Packaging

1 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
Inhibits the activation of Gq by M1-muscarinic cholinergic receptors

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

H-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH₂

Other Notes

Hunt, R.A., et al. 1999. Hypertension34, 603.
Tsunoda Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 648.
Mukai, H., et al. 1992. J. Biol. Chem.267, 16237.

Safety & Documentation

Safety Information

Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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