• USA Home
  • 373277 - Hh Signaling Antagonist XI, MRT-14 - Calbiochem

EMAIL THIS PAGE TO A FRIEND
373277 Sigma-Aldrich

Hh Signaling Antagonist XI, MRT-14 - Calbiochem

The Hh Signaling Antagonist XI, MRT-14 controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Synonym: Hh Signaling Antagonist XI, MRT-14 - Calbiochem

  • Empirical Formula (Hill Notation) C24H23N3O6

  • Molecular Weight 449.46

Purchase

Properties

assay   ≥98% (HPLC)
form   powder
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   white
solubility   DMSO: 100 mg/mL
shipped in   ambient

Description

General description

A cell-permeable acylurea compound that acts as an antagonistic Smo ligand (IC50 = 120 nM against 5 nM Bodipy-cyclopamine binding to murine Smo-transfected HEK293 cells) and is more effective than Cyclopamine (Cat. No. 239803) in inhibiting ShhN-induced Gli transcription in Shh-light 2 cell assays (IC50 = 0.16 and 0.3 µM, respectively) and in blocking 0.1 µM SAG- (Cat. Nos. 566660 and 566661) stimulated differentiation of C3H10T1/2 murine mesenchymal stem cells into osteoblasts (IC50 = 0.13 and 0.62 µM, respectively).

A cell-permeable acylurea compound that acts as an antagonistic Smo ligand (IC50 = 120 nM against 5 nM Bodipy-cyclopamine binding to murine Smo-transfected HEK293 cells) and is more effective than Cyclopamine (Cat. No. 239803) in inhibiting ShhN-induced Gli transcription in Shh-light 2 cell assays (IC50 = 0.16 and 0.3 µM, respectively) and in blocking 0.1 µM SAG- (Cat. Nos. 566660 & 566661) stimulated differentiation of C3H10T1/2 murine mesenchymal stem cells into osteoblasts (IC50 = 0.13 and 0.62 µM, respectively).

The Hh Signaling Antagonist XI, MRT-14 controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Packaging

10 mg in Glass bottle

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Manetti, F., et al. 2010. Mol. Pharmacol.78, 658.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?