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  • 375670 - Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem

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375670 Sigma-Aldrich

Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem

A potent and cell-permeable protein tyrosine kinase inhibitor.

  • CAS Number 70563-58-5

  • Empirical Formula (Hill Notation) C30H42N2O9

  • Molecular Weight 574.66

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, P to Q,
packaging   100 μg in Glass bottle (375670-100UG)
color   yellow
form   solid
shipped in   ambient
solubility   DMSO: 1 mg/mL
storage condition   OK to freeze
  protect from light
brand family   Calbiochem
primary target IC50   12 µM against P60v-src
purity   ≥95% by HPLC
storage conditions   -20C

Description

Biochem/physiol Actions

Cell permeable: yes

Primary Target
P60v-src

Product does not compete with ATP.

Reversible: no

Target IC50: 12 µM against P60v-src

General description

A cell-permeable, potent inhibitor of protein tyrosine kinases. Inhibits p60v-src (IC50 = 12 µM) autophosphorylation. Irreversibly binds to the sulfhydryl groups of the kinase. Dose-dependently inhibits PDGF-induced phospholipase D activation (IC50 = 8 µg/ml). Also, reported to inhibit c-src related bone resorption (IC50 = 70 nM). Inhibits angiogenesis in chick chorioallantoic membrane and blocks anti-CD3 monoclonal antibody-induced apoptosis of thymocytes. Several mammalian cell lines transformed with tyrosine kinase oncogenes (src, abl, fps, ros, yes, erbB) show reversion from the transformed to the normal phenotype after treatment with herbimycin A.

A potent and cell-permeable protein tyrosine kinase inhibitor. Inhibits p60v-src(IC50 = 12 µM) and PDGF-induced phospholipase D activation (IC50 = 8 µg/ml). Reported to inhibit c-Src related bone resorption (IC50 = 70 nM). Inhibits angiogenesis in chick chorioallantoic membrane. Also shown to inhibit anti-CD3 monoclonal antibody-induced apoptosis of thymocytes.

Other Notes

Fan, T.-P., et al. 1995. Trends Pharmacol. Sci. 16, 57.
Kim, B.Y. 1995. Biochem. Biophys. Res. Commun.212, 1061.
Migita, K., et al. 1994. J. Immunol.153, 3457.
Okabe, M., et al. 1994. Leuk. Res. 18, 867.
Fukazawa, H., et al. 1991. Biochem. Pharmacol.42, 1661.
Obinata, A., et al. 1991. Exp. Cell Res.193, 36.
Park, D.J., et al. 1991. J. Biol. Chem.266, 24237.
Weinstein, S.L., et al. 1991. Proc. Natl. Acad. Sci. USA88, 4148.
Oikawa, T., et al. 1989. Cancer Lett.48, 157.
Uehara, Y., et al. 1989. Biochem. Biophys. Res. Commun.163, 803.
Uehara, Y., et al. 1988. Virology164, 294.
Omura, S., et al. 1979. J. Antibiotics32, 255.

Packaging

100 μg in Glass bottle

Preparation Note

Further dilute with H₂O or aqueous buffers just prior to use.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.

Warning

Carcinogenic / Teratogenic (D)

Safety & Documentation

Safety Information

RTECS 
LX8930000

Documents

Certificate of Analysis

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Protocols & Articles
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