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382425 Sigma-Aldrich

Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem

Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC₅₀ = 300 pM) and platelet aggregation in vitro.

Synonym: 9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725, Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem

  • CAS Number 78416-81-6

  • Empirical Formula (Hill Notation) C24H27N3O3 · xHCl

  • Molecular Weight 405.49 (free base basis)

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors More...
Quality Level   100
assay   ≥98% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   +15C to +30C
color   pale yellow
solubility   water: 500 μM
shipped in   ambient

Description

General description

Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 300 pM) and platelet aggregation in vitro. Potentiates adenosine-stimulated cAMP accumulation.

Packaging

10 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
cGMP-inhibited phosphodiesterase

Product does not compete with ATP.

Reversible: no

Target IC50: 300 pM against cGMP-inhibited phosphodiesterase

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Spina, D., et al. 1998. Life Sci. 62, 953.
Pillai, R., et al. 1994. J. Biol. Chem.269, 30676.
Tang, K.M., et al. 1994. Eur. J. Pharmacol.268, 105.
Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci.11, 150.
DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
Ruppert, D., and Weithmann, K.U. 1982. Life Sci.31, 2037.

Safety & Documentation

Safety Information

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