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Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem

Caspase-1 Inhibitor II, CAS 178603-78-6, is a cell-permeable, irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5.

Synonym: IL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK, IL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK

  • CAS Number 178603-78-6

  • Empirical Formula (Hill Notation) C24H33ClN4O8

  • Molecular Weight 540.99

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Properties

Related Categories A to C, Biochemicals and Reagents, Caspase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
packaging   5 mg in Plastic ampoule (400012-5MG)
feature productdata solubility   DMSO (5 mg/ml)
brand family   Calbiochem
form   White solid
primary target Ki   760 pM against caspase-1
purity   ≥95% by HPLC
shipped in   ambient
storage conditions   -20C
  Protect from moisture
  Ok to freeze

Description

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-1

Product does not compete with ATP.

Reversible: no

General description

A cell-permeable and irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.

Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.

Other Notes

Brenner, B., et al. 1998. Cell Death Differ. 5, 29.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Schlegel, J., et al. 1996. J. Biol. Chem.271, 1841.
Enari, M., et al. 1995. Nature375, 78.
Walker, N.P.C., et al. 1994. Cell78, 343.
Thornberry, N., et al. 1992. Nature356, 768.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Standard Handling (A)

Sequence

Ac-Tyr-Val-Ala-Asp-CMK

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles
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