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Caspase-1 Inhibitor IV - CAS 154674-81-4 - Calbiochem

The Caspase-1 Inhibitor IV, also referenced under CAS 154674-81-4, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym: ICE Inhibitor IV, Ac-YVAD-AOM, ICE Inhibitor IV, Ac-YVAD-AOM

  • CAS Number 154674-81-4

  • Empirical Formula (Hill Notation) C33H42N4O10

  • Molecular Weight 654.71

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Properties

Related Categories A to C, Biochemicals and Reagents, Caspase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
packaging   1 mg in Plastic ampoule (400015-1MG)
feature productdata solubility   DMSO (5 mg/ml)
brand family   Calbiochem
form   White solid
purity   ≥96% by HPLC
shipped in   ambient
storage conditions   -20C
  Protect from moisture
  Ok to freeze

Description

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-1

Product does not compete with ATP.

Reversible: no

General description

A highly selective, competitive, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.

Highly selective, competitive and irreversible inhibitor of caspase-1 and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles, such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.

Other Notes

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.

Reconstitution

Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Standard Handling (A)

Sequence

Ac-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles
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