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400046 Sigma-Aldrich

Hydroxyurea - CAS 127-07-1 - Calbiochem

Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.

Synonym: Hydroxyurea - CAS 127-07-1 - Calbiochem, Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I

  • CAS Number 127-07-1

  • Empirical Formula (Hill Notation) CH4N2O2

  • Molecular Weight 76.05

  •  MDL number MFCD00007943

  •  NACRES NA.77

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Properties

Quality Level   100
assay   ≥98% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   +2C to +8C
color   white
solubility   water: 5 mg/mL
shipped in   ambient
InChI   1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
InChI key   VSNHCAURESNICA-UHFFFAOYSA-N

Description

General description

Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.

Antineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.

Packaging

5 g in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
Inhibiting ribonucleotide reductase

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.

Other Notes

Leyden, D., et al. 2000. Anticancer Res.20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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