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400084 Sigma-Aldrich

HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem

Synonym: HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem

  • CAS Number 385786-48-1

  • Empirical Formula (Hill Notation) C21H16ClN3O

  • Molecular Weight 361.82

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Properties

Quality Level   100
assay   ≥95% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   -20C
color   tan
solubility   DMSO: 50 mg/mL
shipped in   ambient

Description

General description

A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.

Packaging

10 mg in Glass bottle

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Smirnova, N.A., et al. 2010. Chem. Biol.4, 380.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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