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401474 Millipore

IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem

IKK Inhibitor II, Wedelolactone, CAS 524-12-9, is a cell-permeable, selective, irreversible inhibitor of IKKα and β kinase activity (IC50 = 10 µM).

Synonym: Wedelolactone, Eclipta alba, 7-Methoxy-5,11,12-trihydroxy-coumestan, Wedelolactone, Eclipta alba, 7-Methoxy-5,11,12-trihydroxy-coumestan

  • CAS Number 524-12-9

  • Empirical Formula (Hill Notation) C16H10O7

  • Molecular Weight 314.25

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience More...
packaging   1 mg in Plastic ampoule (401474-1MG)
feature productdata solubility   DMSO (5 mg/ml) or Methanol (1 mg/ml)
brand family   Calbiochem
form   Yellowish-green, crystalline powder
primary target IC50   < 10 µM against IKKα and β kinase activity
purity   ≥95% by HPLC
shipped in   ambient
storage conditions   +2C to +8C
  Protect from light
  Ok to freeze

Description

Biochem/physiol Actions

Cell permeable: yes

Primary Target
IKKα and β kinase activity

Product does not compete with ATP.

Reversible: no

General description

Cell-permeable. The naturally-occuring active ingredient from the herbal medicine, Eclipta alba, that acts as a selective and irreversible inhibitor of IKKα and IKKβ kinase activities (IC50< 10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Does not affect the activities of p38 MAP kinase or Akt.

The naturally isolated active ingredient of the herbal medicine, Eclipta alba, that acts as a cell permeable, selective and irreversible inhibitor of IKKα and β kinase activity (IC50< 10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Has no effects on p38 MAP kinase or Akt.

Other Notes

Kobori, M., et al. 2004. Cell Death Differ.11, 123.
Li, C.C., et al. 2003. J. Org. Chem.68, 8500.
Mors, W.B., et al. 1989. Toxicon27, 1003.
Wagner, H., and Fessler, B. 1986. Planta Med.5, 374.

Packaging

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Standard Handling (A)

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles
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