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  • 407601 - Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem

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407601 Sigma-Aldrich

Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem

The Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor controls the activity of Interleukin-1 Receptor-Associated-Kinase-1/4. Primarily used for Phosphorylation & Dephosphorylation apps.

Synonym: IRAK-1/4 Inhibitor, N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem

  • CAS Number 509093-47-4

  • Empirical Formula (Hill Notation) C20H21N5O4

  • Molecular Weight 395.41

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Properties

Quality Level   100
assay   ≥98% (HPLC)
form   crystalline solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   -20C
color   yellow
solubility   DMSO: 10 mg/mL
shipped in   ambient

Description

General description

A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src. Also available as a 25 mM solution in DMSO (Cat. No. 407602).

A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src.

Packaging

5 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Interleukin-1 receptor-associated kinases

Product does not compete with ATP.

Reversible: no

Target IC50: 300 nM and 200 nM for IRAK-1 and -4

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Other Notes

Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol.293, G429.
Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett.16, 2842.

Safety & Documentation

Safety Information

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