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407616 Sigma-Aldrich

IL-1R Antagonist - CAS 566914-00-9 - Calbiochem

The IL-1R Antagonist, also referenced under CAS 566914-00-9, controls the biological activity of IL-1R.

Synonym: BB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic, IL-1R Antagonist - CAS 566914-00-9 - Calbiochem

  • CAS Number 566914-00-9

  • Empirical Formula (Hill Notation) C18H26N2O2

  • Molecular Weight 302.41

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Properties

Related Categories Antagonists, Cell Biology, Cell Signaling and Neuroscience, Endothelins, Peptides and Proteins,
Quality Level   100
assay   ≥95% (HPLC)
form   oil
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   +2C to +8C
color   colorless
solubility   DMSO: 10 mg/mL
  ethanol: soluble
shipped in   ambient

Description

General description

A cell-permeable, end protected L-valyl derivative modeled on the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.

A cell-permeable, end protected L-valyl derivative of the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.

Packaging

10, 25 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
TIR domain-mediated MyD88/IL1-RI interaction

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7971.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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