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410957 Sigma-Aldrich

3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem

A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM).

Synonym: 3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem, IBMX

  • CAS Number 28822-58-4

  • Empirical Formula (Hill Notation) C10H14N4O2

  • Molecular Weight 222.24

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors More...
Quality Level   100
assay   ≥98% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   -20C
color   white
solubility   ethanol: 10 mg/mL
  DMSO: 100 mM
  methanol: 50 mg/mL
shipped in   ambient

Description

General description

A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-α expression in adipocyte precursor cells.

A non-specific, cell-permeable inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNFα expression in adipocyte precursor cells.

Packaging

1 g in Plastic ampoule

250 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
cAMP and cGMP phosphodiesterases

Product does not compete with ATP.

Reversible: no

Target IC50: 2-50 µM against cAMP and cGMP phosphodiesterases

Warning

Toxicity: Standard Handling (A)

Preparation Note

Heating may be required to achieve complete solubilization.

Reconstitution

Following reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.

Other Notes

Hube, F., et al. 1999. Horm. Metab. Res.31, 359.
Morgan, A.J., et al. 1993. Biochem. Pharmacol.45, 2373.
Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci.11, 150.
Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA76, 4451.

Safety & Documentation

Safety Information

RTECS 
ZD8500000
Protocols & Articles
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