• USA Home
  • 420127 - InSolution Jasplakinolide, Jaspis johnstoni - Calbiochem

EMAIL THIS PAGE TO A FRIEND
420127 Sigma-Aldrich

InSolution Jasplakinolide, Jaspis johnstoni - Calbiochem

InSolution Jasplakinolide, Jaspis johnstoni, CAS 102396-24-7, is a 1 mM solution of Jasplakinolide, Jaspis johnstoni in DMSO. Acts as a potent inducer of actin polymerization and stabilization.

Synonym: InSolution Jasplakinolide, Jaspis johnstoni - Calbiochem

  • Empirical Formula (Hill Notation) C36H45BrN4O6

  • Molecular Weight 709.67

Purchase

Properties

Quality Level   100
assay   ≥90% (HPLC)
form   liquid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated (hygroscopic)
  protect from light
storage conditions   -20C
shipped in   wet ice

Description

General description

A cell-permeable F-actin probe. This macrocyclic cyclodepsipeptide, isolated from the marine sponge Jaspis johnstoni, is a potent inducer of actin polymerization and stabilization in vitro. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. Also displays fungicidal, insecticidal, and anticancer properties.

Packaging

50 μg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Kd = 15 nM for actin binding

Primary Target
F-actin

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Physical form

A 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420107) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Rosado, J.A., et al. 2000. J. Biol. Chem.275, 7527.
Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem.274, 4259.
Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst.87, 46.
Bubb, M.R., et al. 1994. J. Biol. Chem.269, 14869.
Scott, V.R., et al. 1988. Antimicrob. Agents Chemother.32, 1154.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

WGK Germany 
WGK 1
Flash Point(F) 
188.6 °F - (Dimethylsulfoxide)
Flash Point(C) 
87 °C - (Dimethylsulfoxide)
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?