• USA Home
  • 420133 - JNK Inhibitor VI, TI-JIP153-163 - Calbiochem

EMAIL THIS PAGE TO A FRIEND
420133 Sigma-Aldrich

JNK Inhibitor VI, TI-JIP153-163 - Calbiochem

The JNK Inhibitor VI, TI-JIP153-163 controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: H₂N-RPKRPTTLNLF-NH₂, Truncated Inhibitor based on JNK- Interacting Protein 1, H₂N-RPKRPTTLNLF-NH₂, Truncated Inhibitor based on JNK-Interacting Protein 1, JNK Inhibitor VI, TI-JIP153-163 - Calbiochem

  • Empirical Formula (Hill Notation) C61H104N20O14

  • Molecular Weight 1341.60

Purchase

Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors,
Quality Level   100
assay   ≥97% (HPLC)
form   lyophilized
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   +2C to +8C
solubility   water: 1 mg/mL
  DMSO: 5 mg/mL
shipped in   ambient

Description

General description

A murine JIP-1 JNK-binding domain- (JBD) derived 11-mer peptide that directly interacts with JNK (KD in low µM range) and specifically inhibits JNK kinase activity without inhibitory effects towards ERK or p38. The inhibition is not limited only to JBD-containing substrates and is found to be mixed/non-competitive with respect to ATP. JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable, is also available (Cat. No. 420134).

Biochem/physiol Actions

Cell permeable: no

Kd in low µM range

Primary Target
JNK

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

H-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Barr, R.K., et al. 2004. J. Biol. Chem.279, 36327.
Barr, R.K., et al. 2002. J. Biol. Chem.277, 10987.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?