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  • 420135 - JNK Inhibitor VIII - CAS 894804-07-0 - Calbiochem

420135 Sigma-Aldrich

JNK Inhibitor VIII - CAS 894804-07-0 - Calbiochem

The JNK Inhibitor VIII, also referenced under CAS 894804-07-0, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: JNK Inhibitor VIII - CAS 894804-07-0 - Calbiochem, N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide

  • CAS Number 894804-07-0

  • Empirical Formula (Hill Notation) C18H20N4O4

  • Molecular Weight 356.38



Quality Level   100
assay   ≥95% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   -20C
color   brown
solubility   DMSO: 10 mg/mL
shipped in   ambient


General description

A cell-permeable pyridinylamide compound that acts as an ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively) and displays excellent selectivity over 72 other kinases. Inhibits c-jun phosphorylation with an EC50 of 920 nM in HepG2 cells. Preferentially blocks the growth of PTEN null mouse embryonic fibroblasts.


5 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Target Ki: 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively


Packaged under inert gas


Toxicity: Standard Handling (A)

Other Notes

Vivanco, I., et al. 2007. Cancer Cell11, 555.
Szczepankiewicz, B. G., et al. 2006. J. Med. Chem.49, 3563.

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