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422689 Sigma-Aldrich

Kir2.1 Inhibitor, ML133 - CAS 185669-79-8 - Calbiochem

The Kir2.1 Inhibitor, ML133, also referenced under CAS 185669-79-8, controls the biological activity of Kir2.1. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym: Inward rectifier potassium channel blocker, ML133

  • CAS Number 185669-79-8

  • Empirical Formula (Hill Notation) C19H19NO

  • Molecular Weight 277.36

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Extracellular Matrix Peptides (ECM), Ion Channels, Laminin Fragments,
packaging   5 mg in Glass bottle (422689-5MG)
color   white
form   solid
shipped in   ambient
solubility   DMSO: 10 mg/mL, clear, colorless
storage condition   OK to freeze
  protect from light
brand family   Calbiochem
purity   ≥95% by HPLC
storage conditions   +2C to +8C

Description

General description

A cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, Kir2.1 (IC50 = 1.8 µM and 290 nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the Kir2.x family, but has no effect on Kir1.1 (IC50 > 300 µM) and displays weak activity for Kir4.1 and Kir7.1 (IC50 = 76 µM and 33 µM, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on Kir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters.

Other Notes

Lindsley, C.W., et al. 2011. ACS Chem. Biol.6, 845.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Standard Handling (A)

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles
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