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428020 Sigma-Aldrich

Latrunculin B, Latrunculia magnifica - CAS 76343-94-7 - Calbiochem

Latrunculin B, CAS 76343-94-7, is a unique marine toxin that inhibits actin polymerization and disrupts microfilament organization. It is 10 to 100-fold more potent than cytochalasins.

Synonym: Latrunculin B, Latrunculia magnifica - CAS 76343-94-7 - Calbiochem

  • CAS Number 76343-94-7

  • Empirical Formula (Hill Notation) C20H29NO5S

  • Molecular Weight 395.51

  •  MDL number MFCD00270879

  •  NACRES NA.77

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Properties

Quality Level   100
assay   ≥95% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   -20C
color   off-white to yellow
solubility   DMSO: 25 mg/mL
  ethanol: 25 mg/mL
  methanol: 50 mg/mL
shipped in   ambient
InChI   1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1
InChI key   NSHPHXHGRHSMIK-JRIKCGFMSA-N

Description

General description

A structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes. 10 to 100-fold more potent than cytochalasins.

A structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes; 10 to 100-fold more potent than cytochalasins.

Packaging

1, 5 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
Actin polymerization

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Harmful (C)

Other Notes

Spector, I., et al. 1989. Cell Motil. Cytoskeleton13, 127.
de Oliveira, C.A., and Mantovani, B. 1988. Life Sci.43, 1825.
Coue, M., et al. 1987. FEBS Lett.213, 316.
Spector, I., et al. 1983. Science219, 493.

Safety & Documentation

Safety Information

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