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434692 Millipore

Leukotriene C₄ - CAS 72025-60-6 - Calbiochem

Synonym: LTC₄, 5(S)-Hydroxy-6(R)-S-glutathionyl-7- trans-9- trans-11- cis-14- cis-eicosatetraenoic Acid, Leukotriene C₄ - CAS 72025-60-6 - Calbiochem

  • CAS Number 72025-60-6

  • Empirical Formula (Hill Notation) C30H47N3O9S

  • Molecular Weight 625.77

  •  MDL number MFCD00151079

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Properties

assay   ≥98% (HPLC)
form   liquid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   = -70C
shipped in   wet ice
InChI   1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1
InChI key   GWNVDXQDILPJIG-NXOLIXFESA-N

Description

General description

This product has been discontinued.



Implicated in renal vasoconstriction associated with sepsis. Also plays a role in bronchioconstriction. Produced by conjugation of LTA4 with reduced glutathione. Reported to be a tight binding inhibitor of microsomal glutathione transferase-1. Has been implicated in pathophysiology of asthma.

Implicated in renal vasoconstriction associated with sepsis. Also plays a role in bronchioconstriction. Produced by conjugation of LTA4 with reduced glutathione. Reported to be a tight binding inhibitor of microsomal glutathione transferase-1. Has been implicated in pathophysiology of asthma.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Microsomal glutathione transferase-1

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Flammable (J)

Physical form

In MeOH:NH₄OAc buffer (65:35), pH 5.6.

Reconstitution

Following initial thaw, aliquor and freeze (-70°C).

Other Notes

Bannenberg, G., et al. 1999. J. Biol. Chem. 274, 1994.
Shimizu, T., et al. 1994. Pediatr. Pulmonol. 18, 129.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Safety & Documentation

Safety Information

RTECS 
MB9143500
Protocols & Articles
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