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437694 Sigma-Aldrich

DL-α-Lipoic Acid, Dihydro- - CAS 462-20-4 - Calbiochem

An effective antioxidant.

Synonym: DHLA, Dihydrolipoic Acid, Thiocytic Acid, Dihydro-, DL-α-Lipoic Acid, Dihydro- - CAS 462-20-4 - Calbiochem

  • CAS Number 462-20-4

  • Empirical Formula (Hill Notation) C8H16O2S2

  • Molecular Weight 208.34

  •  MDL number MFCD00166974

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Properties

Related Categories Antioxidant and Free Radical Scavengers, Cancer Research, Cell Biology, Chemopreventive Agents
Quality Level   100
assay   ≥95% (TLC)
form   liquid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   light yellow
solubility   ethanol: 50 mg/mL
shipped in   ambient
InChI   1S/C8H16O2S2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H,9,10)
InChI key   IZFHEQBZOYJLPK-UHFFFAOYSA-N

Description

General description

An effective antioxidant. Scavenges hypochlorous acid, peroxyl, superoxide, hydroxyl and nitric oxide radicals. Also exhibits prooxidant properties, as demonstrated by its ability to reduce iron ions and to generate reactive sulfur-containing radicals that can damage certain proteins, such as α1-antiproteinase and creatine kinase. DHLA has recently been shown to inhibit apoptosis in rat thymocytes induced by methylprednisolone and etoposide.

An effective antioxidant. Scavenges hypochlorous acid, peroxyl, superoxide, hydroxyl, and nitric oxide radicals. Also exhibits prooxidant properties, as demonstrated by its ability to reduce iron ions and to generate reactive sulfur-containing radicals that can damage certain proteins, such as α1-antiproteinase and creatine kinase. DHLA has recently been shown to inhibit apoptosis in rat thymocytes induced by methylprednisolone and etoposide.

Packaging

50 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
Scavenges hypochlorous acid, peroxyl, superoxide, hydroxyl, and nitric oxide radicals

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Other Notes

Packer, L., et al. 1997. Adv. Pharmacol. 38, 79.
Bustamante, J., et al. 1995. Free Radic. Biol. Med. 19, 339.
Scott, B.C., et al. 1994. Free Radic. Res. 20, 119.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
WGK Germany 
WGK 2
Flash Point(F) 
348.1 °F - Cleveland open cup
Flash Point(C) 
175.6 °C - Cleveland open cup
Protocols & Articles
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